Wednesday, September 28, 2016

Celestoderm-V




Celestoderm-V may be available in the countries listed below.


Ingredient matches for Celestoderm-V



Betamethasone

Betamethasone 17α-valerate (a derivative of Betamethasone) is reported as an ingredient of Celestoderm-V in the following countries:


  • Greece

  • Kenya

  • Lithuania

  • Spain

  • Turkey

Betamethasone valeroacetate (a derivative of Betamethasone) is reported as an ingredient of Celestoderm-V in the following countries:


  • Indonesia

International Drug Name Search

Pentagastrin




In the US, Pentagastrin is a member of the drug class miscellaneous uncategorized agents.

UK matches:

  • Pentagastrin Injection BP (Cambridge Laboratories)
  • Pentagastrin Injection BP (Cambridge Laboratories) (SPC)

Scheme

Rec.INN

ATC (Anatomical Therapeutic Chemical Classification)

V04CG04

CAS registry number (Chemical Abstracts Service)

0005534-95-2

Chemical Formula

C37-H49-N7-O9-S

Molecular Weight

767

Therapeutic Categories

Diagnostic agent, gastric function

Gastric secretory stimulant

Chemical Name

L-Phenylalaninamide, N-[(1,1-dimethylethoxy)carbonyl]-ß-alanyl-L-tryptophyl-L-methionyl-L-α-aspartyl-

Foreign Names

  • Pentagastrinum (Latin)
  • Pentagastrin (German)
  • Pentagastrine (French)
  • Pentagastrina (Spanish)

Generic Names

  • Pentagastrin (OS: JAN, USAN, BAN)
  • Pentagastrine (OS: DCF)
  • AY 6608 (IS)
  • ICI 50123 (IS)
  • Pentagastrin (PH: BP 2010)

Brand Names

  • Pentagastrin
    Cambridge Laboratories, United Kingdom


  • Peptavlon
    SERB, France

International Drug Name Search

Glossary

BANBritish Approved Name
DCFDénomination Commune Française
ISInofficial Synonym
JANJapanese Accepted Name
OSOfficial Synonym
PHPharmacopoeia Name
Rec.INNRecommended International Nonproprietary Name (World Health Organization)
SPC Summary of Product Characteristics (UK)
USANUnited States Adopted Name

Click for further information on drug naming conventions and International Nonproprietary Names.

Orapred Solution


Pronunciation: pred-NIS-oh-lone SO-dee-uhm FOSS-fate
Generic Name: Prednisolone Sodium Phosphate
Brand Name: Orapred


Orapred Solution is used for:

Treating severe allergies, arthritis, asthma, certain blood disorders, and skin conditions. It may also be used for other conditions as determined by your doctor.


Orapred Solution is a corticosteroid. It works by modifying the body's immune response to various conditions and decreasing inflammation.


Do NOT use Orapred Solution if:


  • you are allergic to any ingredient in Orapred Solution

  • you have a systemic fungal infection, a certain type of malaria, inflammation of the optic nerve, or herpes infection of the eye

  • you are scheduled to have a live or attenuated live vaccination (eg, smallpox)

  • you are taking mifepristone

Contact your doctor or health care provider right away if any of these apply to you.



Before using Orapred Solution:


Some medical conditions may interact with Orapred Solution. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:


  • if you are pregnant, planning to become pregnant, or are breast-feeding

  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

  • if you have allergies to medicines, foods, or other substances

  • if you have a history of heart problems (eg, congestive heart failure), heart attack, high blood pressure, kidney problems, liver problems, diabetes, seizures, an underactive thyroid, adrenal gland problems, or any mental or mood problems

  • if you have or have recently had a fungal, bacterial, viral, or other type of infection; herpes infection of the eye; chickenpox; measles; or shingles

  • if you have HIV infection or tuberculosis (TB) infection, or if you have had ever had a positive TB skin test

  • if you have any stomach problems (eg, ulcers), intestinal problems (eg, blockage, perforation, or infection; unexplained diarrhea; diverticulitis; ulcerative colitis), recent intestinal surgery, or inflammation of the esophagus

  • if you have weak bones (eg, osteoporosis) or muscle problems (eg, myasthenia gravis)

  • if you have had a recent vaccination (eg, smallpox)

Some MEDICINES MAY INTERACT with Orapred Solution. Tell your health care provider if you are taking any other medicines, especially any of the following:


  • Barbiturates (eg, phenobarbital), carbamazepine, ephedrine, hydantoins (eg, phenytoin), or rifampin because they may decrease Orapred Solution's effectiveness

  • Clarithromycin, cyclosporine, estrogens (eg, estradiol), oral contraceptives (eg, birth control pills), or ketoconazole because they may increase the risk of Orapred Solution's side effects

  • Anticholinesterases (eg, pyridostigmine), aspirin, diuretics, furosemide, hydrochlorothiazide, live or attenuated live vaccines (eg, smallpox), methotrexate, mifepristone, or ritodrine because the risk of their side effects may be increased by Orapred Solution

  • Anticoagulants (eg, warfarin) or killed or inactivated vaccines because their effectiveness may be decreased by Orapred Solution

This may not be a complete list of all interactions that may occur. Ask your health care provider if Orapred Solution may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.


How to use Orapred Solution:


Use Orapred Solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.


  • Take Orapred Solution by mouth with food.

  • Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.

  • If you miss a dose of Orapred Solution and you are taking 1 dose daily, take it as soon as possible. If you do not remember until the next day, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Orapred Solution.



Important safety information:


  • Orapred Solution may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.

  • If you have not had chickenpox, shingles, or measles, avoid contact with anyone who does.

  • Report to your doctor any injuries or signs of infection (fever, sore throat, pain during urination, or muscle aches) for up to 12 months after stopping Orapred Solution.

  • Carry an ID card at all times that says you take Orapred Solution.

  • Do not receive a live vaccine (eg, measles, mumps) while you are taking Orapred Solution. Talk with your doctor before you receive any vaccine.

  • Tell your doctor or dentist that you take Orapred Solution before you receive any medical or dental care, emergency care, or surgery.

  • Diabetes patients - Orapred Solution may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.

  • Lab tests, including adrenal function tests, may be performed while you use Orapred Solution. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.

  • Caution is advised when using Orapred Solution in CHILDREN; they may be more sensitive to its effects.

  • Corticosteroids may affect growth rate in CHILDREN and teenagers in some cases. They may need regular growth checks while they take Orapred Solution.

  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Orapred Solution while you are pregnant. Orapred Solution is found in breast milk. If you are or will be breast-feeding while you use Orapred Solution, check with your doctor. Discuss any possible risks to your baby.

If you are on long-term or high dosage therapy and you suddenly stop taking Orapred Solution, you may have WITHDRAWAL symptoms, including fever, vomiting, appetite loss, diarrhea, nausea, dizziness, weight loss, weakness, general body discomfort, or joint or muscle pain.



Possible side effects of Orapred Solution:


All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:



Acne; clumsiness; dizziness; facial flushing; feeling of a whirling motion; general body discomfort; headache; increased appetite; increased sweating; nausea; nervousness; sleeplessness; upset stomach.



Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry stools; changes in body fat; changes in menstrual period; changes in skin color; chest pain; easy bruising or bleeding; infection (eg, fever, chills, sore throat); mental or mood changes (eg, depression); muscle pain, weakness, or wasting; seizures; severe nausea or vomiting; sudden severe dizziness or headache; swelling of feet or legs; tendon or bone pain; thinning of skin; unusual skin sensation; unusual weight gain; vision changes or other eye problems; vomit that looks like coffee grounds.



This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.


See also: Orapred side effects (in more detail)


If OVERDOSE is suspected:


Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.


Proper storage of Orapred Solution:

Check with your pharmacist for storage instructions. Some brands of Orapred Solution (eg, Orapred) must be stored in the refrigerator, between 36 and 46 degrees F (2 and 8 degrees C). Others may be stored at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Do not freeze. Keep Orapred Solution out of the reach of children and away from pets.


General information:


  • If you have any questions about Orapred Solution, please talk with your doctor, pharmacist, or other health care provider.

  • Orapred Solution is to be used only by the patient for whom it is prescribed. Do not share it with other people.

  • If your symptoms do not improve or if they become worse, check with your doctor.

  • Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Orapred Solution. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.



Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Orapred resources


  • Orapred Side Effects (in more detail)
  • Orapred Use in Pregnancy & Breastfeeding
  • Orapred Drug Interactions
  • Orapred Support Group
  • 2 Reviews for Orapred - Add your own review/rating


Compare Orapred with other medications


  • Asthma, acute
  • Bronchopulmonary Dysplasia
  • Bullous Pemphigoid
  • Dermatitis
  • Immunosuppression
  • Inflammatory Conditions
  • Multiple Sclerosis
  • Nephrotic Syndrome
  • Pemphigoid
  • Pemphigus

methoxsalen


meth-OX-a-len


Oral route(Capsule)

Methoxsalen with UV radiation should be used only by physicians who have special competence in diagnosis and treatment of psoriasis and who have special training and experience in photochemotherapy. Photochemotherapy should be restricted to patients with severe, recalcitrant, disabling psoriasis which is not adequately responsive to other forms of therapy. Risks of therapy include ocular damage, aging of the skin, and skin cancer (including melanoma). The soft gelatin capsules should not be used interchangeably with regular methoxsalen hard gelatin capsules due to greater bioavailability and earlier photosensitization onset time .



Commonly used brand name(s)

In the U.S.


  • 8-Mop

  • Oxsoralen-Ultra

Available Dosage Forms:


  • Capsule

Therapeutic Class: Antipsoriatic


Chemical Class: Psoralen


Uses For methoxsalen


Methoxsalen belongs to the group of medicines called psoralens. It is used along with ultraviolet light (found in sunlight and some special lamps) in a treatment called PUVA to treat vitiligo, a disease in which skin color is lost, and psoriasis, a skin condition associated with red and scaly patches.


Methoxsalen is also used with ultraviolet light in the treatment of white blood cells. This treatment is called photopheresis and is used to treat the skin problems associated with mycosis fungoides, which is a type of lymphoma.


Methoxsalen may also be used for other conditions as determined by your doctor.


methoxsalen is available only with your doctor's prescription.


Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in the product labeling, methoxsalen is used in certain patients with the following medical conditions:


  • Alopecia areata

  • Atopic dermatitis

  • Eczema

  • Lichen planus

  • Skin that is abnormally sensitive to sunlight

Before Using methoxsalen


In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For methoxsalen, the following should be considered:


Methoxsalen is a very strong medicine that increases the skin's sensitivity to sunlight. In addition to causing serious sunburns if not properly used, it has been reported to increase the chance of skin cancer and cataracts. Also, like too much sunlight, PUVA can cause premature aging of the skin. Therefore, methoxsalen should be used only as directed and it should not be used simply for suntanning. Before using methoxsalen, be sure that you have discussed its use with your doctor.


Allergies


Tell your doctor if you have ever had any unusual or allergic reaction to methoxsalen or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Pediatric


Some of the side effects are more likely to occur in children up to 12 years of age, since these children may be more sensitive to the effects of methoxsalen.


Geriatric


Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of methoxsalen in the elderly with use in other age groups.


Pregnancy








Pregnancy CategoryExplanation
All TrimestersCAnimal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding


There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.


Interactions with Medicines


Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking methoxsalen, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.


Using methoxsalen with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.


  • Phenytoin

Interactions with Food/Tobacco/Alcohol


Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.


Other Medical Problems


The presence of other medical problems may affect the use of methoxsalen. Make sure you tell your doctor if you have any other medical problems, especially:


  • Allergy to sunlight (or family history of) or

  • Infection or

  • Lupus erythematosus or

  • Porphyria or

  • Skin cancer (history of) or

  • Skin conditions (other) or

  • Stomach problems—Use of PUVA may make the condition worse

  • Eye problems, such as cataracts or loss of the lens of the eye—The light treatment may make the condition worse or may cause damage to the eye

  • Heart or blood vessel disease (severe)—The heat or prolonged standing associated with each light treatment may make the condition worse

  • Liver disease—Condition may cause increased blood levels of the medicine and cause an increase in side effects

Proper Use of methoxsalen


Eating certain foods while you are taking methoxsalen may increase your skin's sensitivity to sunlight. To help prevent this, avoid eating limes, figs, parsley, parsnips, mustard, carrots, and celery while you are being treated with methoxsalen.


Methoxsalen usually comes with patient directions. Read them carefully before using methoxsalen.


methoxsalen may take 6 to 8 weeks to really help your condition. Do not increase the amount of methoxsalen you are taking or spend extra time in the sunlight or under an ultraviolet lamp. This will not make the medicine act any more quickly and may result in a serious burn.


If methoxsalen upsets your stomach:


  • Patients taking the hard gelatin capsules may take them with food or milk.

  • Patients taking the soft gelatin capsules may take them with low-fat food or low-fat milk.

Dosing


The dose of methoxsalen will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of methoxsalen. If your dose is different, do not change it unless your doctor tells you to do so.


The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.


  • For oral dosage form (hard gelatin capsule):
    • For treating mycosis fungoides and psoriasis:
      • Adults and children 12 years of age and over—Dose is based on body weight and must be determined by your doctor. However, the usual dose is 0.6 mg per kilogram (kg) (0.27 mg per pound) of body weight taken two hours before UVA exposure. This treatment (methoxsalen and UVA) is given two or three times a week with the treatment spaced at least forty-eight hours apart.

      • Children up to 12 years of age—Dose must be determined by your doctor.


    • For vitiligo:
      • Adults and children 12 years of age and over—20 milligrams (mg) per day taken two to four hours before ultraviolet light A (UVA) exposure. This treatment (methoxsalen and UVA) is given two or three times a week with the treatment spaced at least forty-eight hours apart.

      • Children up to 12 years of age—Dose must be determined by your doctor.



  • For oral dosage form (soft gelatin capsule):
    • For psoriasis:
      • Adults and children 12 years of age and over—Dose is based on body weight and must be determined by your doctor. The usual dose is 0.4 mg per kg (0.18 mg per pound) of body weight taken one and one-half to two hours before UVA exposure. This treatment (methoxsalen and UVA) is given two or three times a week, with the treatment spaced at least forty-eight hours apart.

      • Children up to 12 years of age—Dose must be determined by your doctor.



Missed Dose


Call your doctor or pharmacist for instructions.


If you are late in taking, or miss taking, a dose of methoxsalen, notify your doctor so your light treatment can be rescheduled. Remember that exposure to sunlight or ultraviolet light must take place a certain number of hours after you take the medicine or it will not work. For patients taking the hard gelatin capsules, this is 2 to 4 hours. For patients taking the soft gelatin capsules, this is 1½ to 2 hours. If you have any questions about this, check with your doctor.


Storage


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.


Keep out of the reach of children.


Do not keep outdated medicine or medicine no longer needed.


Precautions While Using methoxsalen


Your doctor should check your progress at regular visits to make sure methoxsalen is working and that it does not cause unwanted effects. Eye examinations should be included.


methoxsalen increases the sensitivity of your skin and lips to sunlight. Therefore, exposure to the sun, even through window glass or on a cloudy day, could cause a serious burn. If you must go out during the daylight hours:


  • Before each treatment, cover your skin for at least 24 hours by wearing protective clothing, such as long-sleeved shirts, full-length slacks, wide-brimmed hat, and gloves. In addition, protect your lips with a special sun block lipstick that has a skin protection factor (SPF) of at least 15. Check with your doctor before using sun block products on other parts of your body before a treatment, since sun block products should not be used on the areas of your skin that are to be treated.

  • After each treatment, cover your skin for at least 8 hours by wearing protective clothing. In addition, use a sun block product that has a skin protection factor (SPF) of at least 15 on your lips and on those areas of your body that cannot be covered.

If you have any questions about this, check with your health care professional.


Your skin may continue to be sensitive to sunlight for some time after treatment with methoxsalen. Use extra caution for at least 48 hours following each treatment if you plan to spend any time in the sun. In addition, do not sunbathe anytime during your course of treatment with methoxsalen.


For 24 hours after you take each dose of methoxsalen, your eyes should be protected during daylight hours with special wraparound sunglasses that totally block or absorb ultraviolet light (ordinary sunglasses are not adequate). This is to prevent cataracts. Your doctor will tell you what kind of sunglasses to use. These glasses should be worn even in indirect light, such as light coming through window glass or on a cloudy day.


methoxsalen may cause your skin to become dry or itchy. However, check with your doctor before applying anything to your skin to treat this problem.


methoxsalen Side Effects


Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.


Check with your doctor immediately if any of the following side effects occur:


  • Blistering and peeling of skin

  • reddened, sore skin

  • swelling (especially of feet or lower legs)

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:


More common
  • Itching of skin

  • nausea

Less common
  • Dizziness

  • headache

  • mental depression

  • nervousness

  • trouble in sleeping

Treatment with methoxsalen usually causes a slight reddening of your skin 24 to 48 hours after the treatment. This is an expected effect and is no cause for concern. However, check with your doctor right away if your skin becomes sore and red or blistered.


There is an increased risk of developing skin cancer after use of methoxsalen. You should check your body regularly and show your doctor any skin sores that do not heal, new skin growths, and skin growths that have changed in the way they look or feel.


Premature aging of the skin may occur as a result of prolonged methoxsalen therapy. This effect is permanent and is similar to what happens when a person sunbathes for long periods of time.


Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.


Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.



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More methoxsalen resources


  • Methoxsalen Dosage
  • Methoxsalen Use in Pregnancy & Breastfeeding
  • Methoxsalen Drug Interactions
  • Methoxsalen Support Group
  • 0 Reviews for Methoxsalen - Add your own review/rating


  • methoxsalen Concise Consumer Information (Cerner Multum)

  • Methoxsalen Hard-Gelatin Capsules MedFacts Consumer Leaflet (Wolters Kluwer)

  • Methoxsalen Professional Patient Advice (Wolters Kluwer)

  • 8-MOP Prescribing Information (FDA)

  • Oxsoralen-Ultra Soft-Gelatin Capsules MedFacts Consumer Leaflet (Wolters Kluwer)

  • Oxsoralen-Ultra Prescribing Information (FDA)

  • Uvadex Prescribing Information (FDA)



Compare methoxsalen with other medications


  • Cutaneous T-cell Lymphoma
  • Psoriasis

Pantozol Control




Pantozol Control may be available in the countries listed below.


Ingredient matches for Pantozol Control



Pantoprazole

Pantoprazole sodium (a derivative of Pantoprazole) is reported as an ingredient of Pantozol Control in the following countries:


  • Austria

  • France

  • Switzerland

International Drug Name Search

Terramycin with Polymyxin B Sulfate




In the US, Terramycin with Polymyxin B Sulfate (oxytetracycline/polymyxin b ophthalmic) is a member of the drug class ophthalmic anti-infectives and is used to treat Conjunctivitis - Bacterial and Eye Dryness/Redness.

US matches:

  • Terramycin with Polymyxin B Sulfate

Ingredient matches for Terramycin with Polymyxin B Sulfate



Oxytetracycline

Oxytetracycline hydrochloride (a derivative of Oxytetracycline) is reported as an ingredient of Terramycin with Polymyxin B Sulfate in the following countries:


  • United States

Polymyxin B

Polymyxin B sulfate (a derivative of Polymyxin B) is reported as an ingredient of Terramycin with Polymyxin B Sulfate in the following countries:


  • United States

International Drug Name Search

Pilopos




Pilopos may be available in the countries listed below.


Ingredient matches for Pilopos



Pilocarpine

Pilocarpine nitrate (a derivative of Pilocarpine) is reported as an ingredient of Pilopos in the following countries:


  • Czech Republic

  • Germany

International Drug Name Search